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Pharmaceutical Raw Powder Brinzolamide For Antiglaucoma CAS 138890-62-7
Birnzolamide;Brinzolamide;2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide,(4R)-;2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (R)-;AL 4862;Brinlolamide;(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide;(4R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide
130.0 to 134.0 °C
It is carbonic anhydrase inhibitors suitable for treating high intraocular pressure or open-angle glaucoma
Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Carbonic anhydrase is found primarily in erythrocytes(but also in other tissues including the eye). It exists as a number of isoenzymes, the most active of which is carbonic anhydrase II (CA-II).
Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.
Shake uniformly before using. As a monotherapy or co-therapy, drop one drop into the conjunctival sac 2 times per day; 3 times a day may be better for some patients.
When use it as a substitute of another anti-glaucoma drug. Stop using that drug first and start using brinzolamide eye drops in the next day.
Treatment with more than one drug should be separated by at least five minutes. It is generally recommended that oppress nasolacrimal duct or gently close your eyes after the medication in order to reduce systemic absorption.
Certificate of Analysis
|Appearance||White to yellow crystalline powder||White crystalline powder|
|Identification||A. Should meet the requirement||Conforms|
|B. Should meet the requirement||Conforms|
|Loss on drying||≤0.5%||0.085%|
|Residue on Ignition||≤0.1%||0.045%|
|Assay||98.0%~102.0% (Calculated on the dried basis)||99.66%|
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