Opioid Pharmaceutical Intermediates U 48800 research chemical Powders CAS 82657-23-6
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CAS: 82657-23-6
Appearance: Powder
Formula: C16H22Cl2N2O
Application: Research
Systematic (IUPAC) name: 3,4-Dichloro-N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N-methylbenzamide
U-48800 is an opioid analgesic drug developed by a team at Upjohn in the 1970s[1] that acts as a selective agonist of the µ-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid receptor[2][3] and has around 7.5 x the potency of morphine in animal models.
U-48800 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-48800 was the most active.
U-48800 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures.
Although not used medically, the selective kappa ligands are used in research.
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| Name |
Replacement |
| Ethylone |
Dibutylone |
| Ethylone |
BK-EDBP |
| a-pvp |
4C-PVP |
| a-pvp |
TH-PVP |
| a-pvp |
4f-php |
| 4-cmc |
2-NMC |
| 4-cmc |
4-CEC |
| 3-cmc |
4-CPRC |
| EP |
Dimethylphenidate(DP) |
| ab-chminaca |
mab-chminaca (MABC) |
| JWH/5F-PB22/FUB-PB22 |
5F-PCN |
| AH-7921 |
U-47700 |
| PB-22/ AM2201 |
FDU-PB-22 |
| AB-FUBINACA |
ADB-FUBINACA |
| SDB-006 |
5F-sdb005 |
| AKB-48 |
FUB-AKB48 |
Company Introduction
Fanchuang Chemicals Biotechnology Co., Limited specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on.
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