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Doripenem Sterile Bulk Drug Intermediates CAS NO 148016-81-3 C15H24N4O6S2 Antibiotics

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Doripenem Sterile Bulk Drug Intermediates CAS NO 148016-81-3 C15H24N4O6S2 Antibiotics

Large Image :  Doripenem Sterile Bulk Drug Intermediates CAS NO 148016-81-3 C15H24N4O6S2 Antibiotics

Product Details:

Place of Origin: China
Brand Name: R&M
Certification: ISO 9001, USP, GMP
Model Number: 01

Payment & Shipping Terms:

Minimum Order Quantity: 1g
Price: negotiation
Packaging Details: vaccum packing of aluminum foil bag
Detailed Product Description
Appearance: White To Off-white Powder Molecular Weight: 420.5
Purity: 99% Cas: 148016-81-3
Name: Doripenem Formula: C15H24N4O6S2

Appearance: white to off-white powder

Molecular Weight: 420.5

Density: 1.59 g/cm3

Boiling Point: 694.8 °C at 760 mmHg

Melting Point: >186°C dec.

Flash Point: 374 °C

Refractive index: 1.68

Usage: Doripenem (CAS NO.148016-81-3) can be used as an antibacterial agent for bacteria infections.

 

Doripenem
Clinical data
Trade names Finibax, Doribax
AHFS/Drugs.com Monograph
MedlinePlus a608015
License data
  • EU EMA: by INN
    US FDA: Doripenem

Pregnancy
category
  • B
Routes of
administration
IM, IV
ATC code
  • J01DH04 (WHO)

Legal status
Legal status
  • US: ℞-only

Pharmacokinetic data
Metabolism Renal
Identifiers
IUPAC name[hide]
  • (4R,5S,6S)-6-(1-Hydroxyethyl)-4-methyl-7-oxo-3-(((5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CAS Number
  • 148016-81-3 [No]

PubChem CID
  • 73303

ChemSpider
  • 66040 [Yes]

UNII
  • BHV525JOBH

KEGG
  • D03895 [Yes]

ChEMBL
  • CHEMBL491571 [Yes]

Chemical and physical data
Formula C15H24N4O6S2
Molar mass 420.50426 g/mol
3D model (JSmol)
  • Interactive image

SMILES[hide]
  • O=S(=O)(N)NC[C@H]3NC[C@@H](SC2=C(N1C(=O)[C@H]([C@H](O)C)[C@H]1[C@H]2C)C(=O)O)C3
InChI[hide]
  • InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
  • Key:AVAACINZEOAHHE-VFZPANTDSA-N

 

Doripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. The usual form is doripenem monohydrate.

 

Doripenem can be used for bacterial infections such as: complex abdominal infections, pneumonia within the setting of a hospital, and complicated infections of the urinary tract including kidney infections with septicemia. Doripenem decreases the process of cell wall growth, which eventually leads to elimination of the infectious cell bacteria altogether.

 

It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem.

 

Doripenem was approved by the United States Food and Drug Administration on October 12, 2007, to be sold under the tradename Doribax. It is the fourth member of the carbapenem class to be approved in the United States. The greater stability of doripenem in aqueous solution compared to earlier members of the carbapenem class allows it to be administered as an infusion over 4 hours or more, which may be advantageous in the treatment of certain difficult-to-treat infections.  It may present a lower risk of inducing seizures than other carbapenems. 

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