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Rizatriptan Pharmaceutical Intermediates CAS NO 144034-80-0 Rizatriptan Benzoate

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Rizatriptan Pharmaceutical Intermediates CAS NO 144034-80-0 Rizatriptan Benzoate

Large Image :  Rizatriptan Pharmaceutical Intermediates CAS NO 144034-80-0 Rizatriptan Benzoate

Product Details:

Place of Origin: China
Brand Name: R&M
Certification: ISO 9001, USP, GMP
Model Number: 01

Payment & Shipping Terms:

Minimum Order Quantity: 1g
Price: negotiation
Packaging Details: vaccum packing of aluminum foil bag
Detailed Product Description
Pro. Name: Rizatriptan Purity: 99%
Cas: 144034-80-0 Residue On Ignition: ≤0.2%
Molecular Formula: C22H25N5O2 Appreance: White To Off-white Crystalline Powder

Rizatriptan Pharmaceutical Intermediates CAS NO 144034-80-0 Rizatriptan Benzoate

 

 

Rizatriptan

Clinical data
Trade names Maxalt
AHFS/Drugs.com Monograph
MedlinePlus a601109
Pregnancy
category
  • B1 (Au), C (U.S.)

Routes of
administration
Oral
ATC code
  • N02CC04 (WHO)

Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 45%
Protein binding 14%
Metabolism by monoamine oxidase
Eliminationhalf-life 2–3 hours
Excretion 82% urine; 12% faeces
Identifiers
IUPAC name[hide]
  • N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
CAS Number
  • 145202-66-0 [Yes]

PubChem CID
  • 5078

IUPHAR/BPS
  • 51

DrugBank
  • DB00953 [Yes]

ChemSpider
  • 4900 [Yes]

UNII
  • WR978S7QHH

KEGG
  • D00675 [No]

ChEBI
  • CHEBI:48273 [Yes]

ChEMBL
  • CHEMBL905 [Yes]

ECHA InfoCard 100.119.030 [Edit this at Wikidata]
Chemical and physical data
Formula C15H19N5
Molar mass 269.345 g/mol
3D model (JSmol)
  • Interactive image

SMILES[hide]
  • n1cncn1Cc2cc3c(cc2)ncc3CCN(C)C
InChI[hide]
  • InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
  • Key:ULFRLSNUDGIQQP-UHFFFAOYSA-N
 

 

Rizatriptan (trade name Maxalt) is a 5-HT1 receptor agonist of the triptan class of drugs developed by Merck & Co. for the treatment of migraine headaches.[1] It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).

 

Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.

 

Rizatriptan is available only by prescription in Australia, Finland, the United States, Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom,Italy (as Rizaliv), France, Israel (as Rizalt), The Netherlands, Croatia and Spain (as Maxalt). It is classified as OTC (over-the-counter) in Brazil (also as Maxalt).

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