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Avibactam Pharmaceutical Intermediates CAS NO 1192500-31-4 Cas 1192491-61-4

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Avibactam Pharmaceutical Intermediates CAS NO 1192500-31-4 Cas 1192491-61-4

Large Image :  Avibactam Pharmaceutical Intermediates CAS NO 1192500-31-4 Cas 1192491-61-4

Product Details:

Place of Origin: China
Brand Name: R&M
Certification: ISO 9001, USP, GMP
Model Number: 01

Payment & Shipping Terms:

Minimum Order Quantity: 1g
Price: negotiation
Packaging Details: vaccum packing of aluminum foil bag
Detailed Product Description
ProName: Avibactam CasNo: 1192491-61-4
Appearance: White Or Off-white Powder Formula: C7H11N3O6S
Molar Mass: 265.24 G/mol Storage: Store The Shade

Avibactam
Clinical data
Trade namesAvycaz (formulated with ceftazidime)
License data
  • EU EMA: by INN

Pregnancy
category
  • US: B (No risk in non-human studies)

Routes of
administration
IV
ATC code
  • None
Legal status
Legal status
  • US: ℞-only

Pharmacokinetic data
Bioavailability100% (intravenous)
Protein binding5.7–8.2%[1]
MetabolismNil
Onset of actionIncreases in proportion to dose
ExcretionRenal (97%)
Identifiers
IUPAC name[hide]
  • [(2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
CAS Number
  • 1192500-31-4

PubChem CID
  • 9835049

ChemSpider
  • 8010770

KEGG
  • D10340

ChEBI
  • CHEBI:85984 [Yes]

ChEMBL
  • CHEMBL1689063

Chemical and physical data
FormulaC7H11N3O6S
Molar mass265.24 g/mol
3D model (JSmol)
  • Interactive image

SMILES[hide]
  • [C@]12C[N@]([C@@H](CC1)C(N)=O)C(=O)N2OS(O)(=O)=O
InChI[hide]
  • InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1
  • Key:NDCUAPJVLWFHHB-UHNVWZDZSA-N

 
Avibactam is a non-β-lactam β-lactamase inhibitor[2] developed by Actavis (now [Teva]) jointly with AstraZeneca. A new drug application for avibactam in combination with ceftazidime (branded as Avycaz) was approved by the FDA on February 25, 2015, for treating complicated urinary tract (cUTI) and complicated intra-abdominal infections (cIAI) caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant Gram-negative bacterial pathogens.
 
Increasing resistance to cephalosporins among Gram-(−) bacterial pathogens, especially among hospital-acquired infections, results in part from the production of β-lactamase enzymes that deactivate these antibiotics. While the co-administration of a β-lactamase inhibitor can restore antibacterial activity to the cephalosporin, previously approved β-lactamase inhibitors such as tazobactam andclavulanic acid do not inhibit important classes of β-lactamases, including Klebsiella pneumoniae carbapenemases (KPCs), New Delhi metallo-β-lactamase 1 (NDM-1), and AmpC-type β-lactamases. Whilst avibactam inhibits class A (KPCs, CTX-M, TEM, SHV), class C (AmpC), and, some, class D serine β-lactamases (such as OXA-23, OXA-48), it has been reported to be a poor substrate/weak inhibitor of class B metallo-β-lactamases, such as VIM-2, VIM-4, SPM-1, BcII, NDM-1, Fez-1.
 

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