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White Power Pimobendan Pharmaceutical Intermediates For Heart Disease , Cas 936727-05-8

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White Power Pimobendan Pharmaceutical Intermediates For Heart Disease , Cas 936727-05-8

Large Image :  White Power Pimobendan Pharmaceutical Intermediates For Heart Disease , Cas 936727-05-8

Product Details:

Place of Origin: China
Brand Name: R&M
Certification: ISO 9001, USP, GMP
Model Number: 01

Payment & Shipping Terms:

Minimum Order Quantity: 1g
Price: negotiation
Packaging Details: vaccum packing of aluminum foil bag
Detailed Product Description
ProName: Pimobendan CasNo: 74150-27-9
Molecular Formula: C19H18N4O2 Appearance: Detailed See Specifications
Storage: Store In Dry, Dark And Ventilated Transportation: By Air Or By Ocean Shipping

Pharmaceutical Intermediates White Power Pimobendan For Heart Disease

 

Pimobendan

Clinical data
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATCvet code
  • QC01CE90 (WHO)

Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 60 to 65%
Eliminationhalf-life 0.4 hours
Excretion In feces
Identifiers
IUPAC name[hide]
  • (RS)-6-[2-(4-Methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-4,5-dihydropyridazin-3(2H)-one
CAS Number
  • 74150-27-9 [Yes]

PubChem CID
  • 4823

ChemSpider
  • 4657 [No]

UNII
  • 34AP3BBP9T

KEGG
  • D01133 [Yes]

ChEMBL
  • CHEMBL24646 [No]

ECHA InfoCard 100.168.193  
Chemical and physical data
Formula C19H18N4O2
Molar mass 334.37 g/mol
3D model (JSmol)
  • Interactive image

Chirality Racemic mixture
SMILES[hide]
  • CC1CC(=O)NN=C1C2=CC3=C(C=C2)N=C(N3)C4=CC=C(C=C4)OC
InChI[hide]
  • InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
  • Key:GLBJJMFZWDBELO-UHFFFAOYSA-N

 

 

 

Pimobendan Basic Information

 

Product Name Pimobendan
Alias pimobendane, tradenames Vetmedin, Acardi, Heartmedin
CAS 74150-27-9
MF C19H18N4O2
MW 334.37
EINECS 211-390-9
Purity 99.50%
Grade Pharmaceutical Grade
Appearance white Crystalline Powder
Brand Nmae HKYC
Standard USP
Stock Mass Stock
Shelf Life 2years
Packing Methods foil bag or as your mind
Delivery time within 18 hours after payment confirmed
Payment T/T, Western Union,Money Gram , Bitcoin
Usage Pimobendan is a cardiotonic agent.
Pimobendan is an antiviral drug. Pimobendan is used to treat heart disease


 

Pimobendan Description


 

Pimobendan is a positive inotrope (increases myocardial contractility). It sensitizes and increases the binding efficiency of cardiac troponin in the myofibril to the calcium ions that are already present in systole. In normal hearts it increases the consumption of oxygen and energy to the same degree as dobutamine but in diseased hearts it may not. Pimobendan also causes peripheral vasodilation by inhibiting the function of phosphodiesterase III. This results in decreased resistance to blood flow through systemic arterioles, which decreases afterload (decreases the failing heart's workload) and reduces the amount of mitral regurgitation.


 

Pimobendan Usage


 

Pimobendan is a cardiotonic agent. The study of the cardiotonic mechanism of Pimobendan using ventricular muscles from rabbits and guinea pigs suggests that Pimobendan acts by inhibiting phosphodiesterase III and potassium channel. The potent venodilating action of Pimobendan makes it a suitable treatment option for patients with congestive heart failure (CHF) as it also improves systemic vasoconstriction.


 

Pimobendan Specification

 

Item Specifications Results
Appearance White or slightly yellowish Powder Slightly yellowish
solubility Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in methanol. Conforms
Identification Infrared absorption spectrophotometry , Comparison pimobendan CRS Conforms
Heavy metals ≤10ppm 1ppm
Water ≤1.0% 0. 1%
Assay (HPLC) 98.0%~100.0% 99.83%
Sulphated ash ≤0.1% 0.01%
Related substances(HPLC) Impurity A:≤0.1% 0.03%
Impurity B:≤0.1% 0.07%
Any other impurity:≤0.1% 0.05%
Total impurity:≤0.2% 0.17%
Conclusion The results conforms with Enterprise standards

 

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