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Natural Caffeine Stimulant Pharmaceutical Raw Materials CAS 58-08-2 White Powder

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Natural Caffeine Stimulant Pharmaceutical Raw Materials CAS 58-08-2 White Powder

Large Image :  Natural Caffeine Stimulant Pharmaceutical Raw Materials CAS 58-08-2 White Powder

Product Details:

Place of Origin: China
Brand Name: FC
Certification: GMP
Model Number: 01

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: foil bag or requirements
Delivery Time: 3-5
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kg
Detailed Product Description
Appearance: White Powder Or Edle Crystal Price: Negotiable
Packing: Foil Bag Name: Caffeine
Color: White Insurance: 100% Rehsip

 

 
Clinical data
Pronunciation /kæˈfiːn, ˈkæfiːn/
Synonyms Guaranine
Methyltheobromine
1,3,7-Trimethylxanthine
Theine
AHFS/Drugs.com Monograph
Pregnancy
category
  • AU: A
    US: C (Risk not ruled out)

Dependence
liability

Physical: low–moderate[1][2][3][4]

Psychological: low[5]

Addiction
liability
Low[4] / none[1][2][3]
Routes of
administration
By mouth, insufflation, enema, rectal, intravenous
Drug class Stimulant
ATC code
  • N06BC01 (WHO)

Legal status
Legal status
  • In general: unscheduled
Pharmacokinetic data
Bioavailability 99%
Protein binding 25–36%
Metabolism Primary: CYP1A2[6]
Minor: CYP2E1,[6]CYP3A4,[6] CYP2C8,[6]CYP2C9[6]
Metabolites Paraxanthine (84%)
Theobromine (12%)
Theophylline (4%)
Onset of action ~1 hour[7]
Elimination half-life Adults: 3–7 hours[6]
Infants: 65–130 hours[6]
Duration of action 3–4 hours[7]
Excretion Urine (100%)
Identifiers
IUPAC name[show]
CAS Number
  • 58-08-2 [☑]

PubChem CID
  • 2519
IUPHAR/BPS
  • 407
DrugBank
  • DB00201
ChemSpider
  • 2424
UNII
  • 3G6A5W338E
KEGG
  • D00528
ChEBI
  • CHEBI:27732
ChEMBL
  • CHEMBL113
PDB ligand
  • CFF (PDBe, RCSB PDB)
ECHA InfoCard 100.000.329
Chemical and physical data
Formula C8H10N4O2
Molar mass 194.19 g/mol
3D model (JSmol)
  • Interactive image
Density 1.23 g/cm3
Melting point 235 to 238 °C (455 to 460 °F) (anhydrous)

 

 

Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class.[10] It is the world's most widely consumed psychoactive drug. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. There are several known mechanisms of action to explain the effects of caffeine. The most prominent is that it reversibly blocks the action of adenosine on its receptor and consequently prevents the onset of drowsiness induced by adenosine. Caffeine also stimulates certain portions of the autonomic nervous system.

Caffeine is a bitter, white crystalline purine, a methylxanthine alkaloid, and is chemically related to the adenine and guanine bases of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It is found in the seeds, nuts, or leaves of a number of plants native to Africa, East Asia and South America,[11] and helps to protect them against predator insects and to prevent germination of nearby seeds.[12] The most well-known source of caffeine is the coffee bean, a misnomer for the seed of Coffea plants. Beverages containing caffeine are ingested to relieve or prevent drowsiness and to improve performance. To make these drinks, caffeine is extracted by steeping the plant product in water, a process called infusion. Caffeine-containing drinks, such as coffee, tea, and cola, are very popular; as of 2014, 85% of American adults consumed some form of caffeine daily, consuming 164 mg on average.[13]

Caffeine can have both positive and negative health effects. It can treat and prevent the premature infant breathing disorders bronchopulmonary dysplasia of prematurity and apnea of prematurity. Caffeine citrate is on the WHO Model List of Essential Medicines.[14] It may confer a modest protective effect against some diseases,[15] including Parkinson's disease.[16] Some people experience sleep disruption or anxiety if they consume caffeine, but others show little disturbance. Evidence of a risk during pregnancy is equivocal; some authorities recommend that pregnant women limit consumption to the equivalent of two cups of coffee per day or less.[17][18] Caffeine can produce a mild form of drug dependence – associated with withdrawal symptoms such as sleepiness, headache, and irritability – when an individual stops using caffeine after repeated daily intake.[1][3][5] Tolerance to the autonomic effects of increased blood pressure and heart rate, and increased urine output, develops with chronic use (i.e., these symptoms become less pronounced or do not occur following consistent use).[19]

Caffeine is classified by the US Food and Drug Administration as "generally recognized as safe" (GRAS). Toxic doses, over 10 grams per day for an adult, are much higher than typical doses of under 500 milligrams per day. A cup of coffee contains 80–175 mg of caffeine, depending on what "bean" (seed) is used and how it is prepared (e.g., drip, percolation, or espresso). Thus it requires roughly 50–100 ordinary cups of coffee to reach a lethal dose. However, pure powdered caffeine, which is available as a dietary supplement, can be lethal in tablespoon-sized amounts.

 

Caffeine

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